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However, not all xenobiotics (including drugs) are conjugated/inactivated by this pathway ( The mercapturic acid pathway ( Figure 1 ) involves the conjugation of the tripeptide, GSH, to xenobiotics (including drugs) to render them more hydrophilic and facilitate their elimination

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Kolevzon A, Angarita B, Bush L, Wang AT, Frank Y, Yang A, et al

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[18] Endogenous vitamin B 12 becomes inactive when exposed to hydrogen cyanide and nitric oxide in cigarette smoke